neurons-AIDS and HIV research citations
Annotated publication timeline
x-axis represents time, y-axis represents article importance (citation-based)
- Pathways to neuronal injury and apoptosis in HIV-associated dementia.
Apr 19, 2001
... and microglia, but not neurons, although neurons are injured and die by apoptosis. The predominant pathway to neuronal ... also contribute. These toxins overstimulate neurons, resulting in the formation of ...
- Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis.
Proc Natl Acad Sci U S A
Aug 26, 1999
... neurons. Thus, apoptosis could occur via direct interaction of gp120 with neurons ... also induced neuronal apoptosis. We could completely abrogate gp120SF2-induced neuronal apoptosis ... death signaling. Moreover, gp120SF2-induced neuronal apoptosis depends predominantly on an ...
- Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.
Jul 02, 1998
... -protein-coupled chemokine receptor in neuronal cell migration and patterning in ...
- Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.
Proc Natl Acad Sci U S A
Dec 28, 1998
... fractalkine, affect neuronal Ca signaling, suggesting that hippocampal neurons possess a wide ... these neurons and reduced voltage-dependent Ca currents in the same neurons ... the chemokine fractalkine in these neurons. Both fractalkine and macrophage-derived ...
- Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.
Proc Natl Acad Sci U S A
Aug 10, 2000
... brain and localized principally to neurons. Central nervous system expression of ... fractalkine regulates cellular communication between neurons (that produce fractalkine) and microglia ... of Akt. Fractalkine protects hippocampal neurons from the neurotoxicity induced by ...
- Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocy
Aug 12, 1999
... culture. Confocal imaging of immunostained neurons demonstrated different patterns of distribution ... , as in leukocytes. Cultured macaque neurons demonstrated calcium flux response to ... of functional chemokine receptors on neurons and astrocytes suggests that chemokines ...
- Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the
Aug 12, 1998
... -associated cytopathicity or apoptosis . Neuronal apoptosis is a feature of ... human neuronal cell line; these cells resemble immature post-mitotic cholinergic neurons and have a number of neuronal characteristics [9 ... directly induce apoptosis in hNT neurons in the absence of CD4 ...
- Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cell
Oct 12, 2000
... an increased incidence of neuronal apoptosis leading to neuronal dropout. Of note ... NT2 cells. For mature, differentiated neurons, apoptosis was also induced in ... in a neuronal precursor cell line and in mature human neurons through ... Vpr-induced apoptosis in human neuronal cells, and suggest that extracellular ...
- Neuronal injury associated with HIV-1: approaches to treatment.
Annu Rev Pharmacol Toxicol
Jul 14, 1998
... have been shown to manifest neuronal injury and apoptotic-like cell ... HIV-1 result in neuronal damage if neurons themselves are only rarely ... one recently defined pathway to neuronal injury, HIV-infected macrophages and ... . A final common pathway for neuronal susceptibility is operative, similar to ...
- Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120
J Acquir Immune Defic Syndr
Oct 23, 2002
... induce apoptosis of cultured neurons and can render neurons vulnerable to excitotoxicity ... . Gp120 and Tat also cause neuronal dysfunction and death in rodents ... . Both gp120 and Tat disrupt neuronal calcium homeostasis by perturbing calcium ... cellular calcium homeostasis can protect neurons against the toxic effects of ...
- Apoptosis and necrosis: two distinct events induced, respectively, by mild and i
Proc Natl Acad Sci U S A
Sep 11, 1995
... report that exposure of cortical neurons to relatively short durations or ... in either apoptotic or necrotic neuronal cell damage.
- Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the a
Mol Cell Biol
Jun 02, 1995
... neuroblastoma cells differentiated to a neuronal phenotype with retinoic acid, TNF ... TNF-alpha induces apoptosis in neuronal cells by a pathway that ...
- Models of neuronal injury in AIDS: another role for the NMDA receptor?
May 28, 1992
... (HIV-1) result in neuronal damage if neurons themselves are not infected ... the injury or demise of neurons via a potentially complex web ... ), astrocytes and neurons. However, a final common pathway for neuronal susceptibility appears ...
- Inhibition of neuronal apoptosis in vitro and in vivo using TAT-mediated protein transduct
Mol Cell Neurosci
Oct 02, 2002
... a feasible technique to rescue neurons from apoptotic degeneration in vitro ... of the fusion protein into neurons. Once inside the cells, TAT ... were prevented from undergoing retrograde neuronal apoptosis caused by optic nerve ...
- HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-m
J Biol Chem
Aug 06, 1998
... nervous system may result in neuronal apoptosis in vulnerable brain regions ... region induce neuronal apoptosis in approximately 50% of vulnerable neurons in both rat and human neuronal cultures, and ... activation of glutamate receptors and neuronal death during HIV-1 infection ...
- CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia trigg
Jun 26, 2001
... -dependent astrocyte-microglia signaling prevent neuronal apoptosis induced by the HIV ... for glia-glia and glia-neuron communication that is relevant to ...
- The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons an
J Exp Med
May 06, 1987
... epitopes of the molecule, CD4+ neurons were defined in the cerebellum ...
- gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective
Dec 13, 1996
... protein gp120 in hippocampal pyramidal neuron cultures. In the presence of ... in culture) than in young neurons (2-7 d in culture ... neurotoxicity was observed in pure neuronal cultures deprived of the glia ... NMDA to increase neuronal [Ca2+]i. The impairment of neuronal Ca2+ homeostasis ...
- Detection of HIV-1 gene sequences in hippocampal neurons isolated from postmortem AIDS bra
J Neuropathol Exp Neurol
Sep 14, 2001
... microdissection to remove individual pyramidal neurons from the CA1, CA3, and ... tissue. They indicate that brain neurons in vivo contain HIV-1 ... suggest that neurons display a selective vulnerability for HIV infection. Neuronal HIV infection could contribute to neuronal injury and death ...
- Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brai
May 14, 2003
... the infection of oligodendrocytes and neurons is debated. In this study ... CD68 (microglia), GFAP (astrocytes), MAP2 (neurons), and p24 (HIV-1 positive ... astrocytes, and 100 to 200 neurons in HIV-1 positive cases ... , the infection of astrocytes and neurons by HIV-1 may contribute ...
- Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloi
J Exp Med
May 02, 1995
... hAPP isoforms were expressed in neurons of gp120/hAPP-bigenic mice ... moderate levels showed significantly less neuronal loss, synapto-dendritic degeneration, and ... /or on the level of neuronal hAPP expression. Hence, molecules that ...
- The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.
Mar 03, 1988
... . Absence of cytolytic infection of neurons, oligodentrocytes, and astrocytes has focused ...
- Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxici
Aug 24, 1998
Apoptosis of neurons and non-neuronal cells has been demonstrated in ... can potentiate the induction of neuronal apoptosis compared with exposure to ... completely abolish the induction of neuronal apoptosis by Tat, suggesting that ... new therapeutic strategies to prevent neuronal cell death and improve neurologic ...
- Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral
Mar 07, 1997
... microglia, astrogliosis, and neuronal injury or loss. Recently, neuronal and other cell ... HIV-1 result in neuronal damage if neurons themselves are only rarely ... one recently defined pathway to neuronal injury, HIV-infected macrophages/ microglia ... . A final common pathway for neuronal susceptibility appears to be operative ...
- Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.
Sep 06, 2010
... ) protects against HIV/gp120-mediated neuronal damage in culture and in ... -I treatment prevented gp120-mediated neuronal loss, but did not alter ... ), which has been associated with neuronal damage and loss. In the ...
- Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS.
Am J Pathol
May 21, 2003
... found proteins induced in cortical neurons (ie, cyclin D3, tissue transglutaminase ... their subsequent detrimental effects on neurons. These data support the hypothesis ... CNS dysfunction by directly damaging neurons, as well as by induction ... and protein expression profiles in neurons themselves which are deleterious to ...
- Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not
Dec 10, 1990
... ), injured rat retinal ganglion cell neurons in culture. This form of ... T cells, did not prevent neuronal injury induced by gp120. These ... suggest that injury of central neurons engendered by gp120 may be ... deleterious effects of gp120 on neurons may not be mediated via ...
- Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons throu
Oct 28, 2004
... protein gp120 (glycoprotein 120) induces neuronal apoptosis and has been implicated ... production of ceramide in primary neurons. Antisense knockdown of neutral (NSMase ... neuronal apoptosis. Similarly, the HIV-1 regulatory protein Tat also induced neuronal ...
- Regulation of neuronal SNARE assembly by the membrane.
Nat Struct Biol
May 27, 2003
In the neuron, SNARE (soluble N-ethylmaleimide-sensitive ...
- CD4-independent, productive infection of a neuronal cell line by human immunodeficiency vi
Mar 26, 1990
One neuronal cell line (SK-N-MC) ... they express dopamine hydroxylase, catecholamines, neuron-specific enolase, and neurofilaments. Despite ...
- Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice.
Mar 03, 2011
... immunofluorescence brain tissue examinations for neuronal and glial markers, captured by ... emission, showed regional reduction of neuronal soma and synaptic architectures. This ... , to our knowledge, demonstrating lost neuronal integrity after HIV-1 infection ...
- NF-kappa B activates the HIV promoter in neurons.
Dec 06, 1993
... using transgenic mice indicates that neurons possess transcription factors capable of ... of primary cultures of rat neurons with HIV promoter-reporter gene ... and immunological analyses indicate that neuronal NF-kappa B is similar ... other tissues. Transfections of primary neuron cultures with an HIV promoter ...
- Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes.
May 19, 2011
... outgrowth from hippocampal neurons and increased survival of cortical neurons upon hydrogen ... neuronal cell surface. The data indicate that, under conditions of high neuronal ... outgrowth and neuronal survival by modulating the interactions between glia and neurons.
- Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes
Nov 05, 1998
... from demented patients induced greater neuronal death than viruses from nondemented ...
- HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration.
Apr 05, 2007
... persons. Moreover, soluble Vpr caused neuronal apoptosis, involving cytochrome c extravasation ... neurons and was blocked by anti-Vpr antibody (p < 0.05). Neuronal ... transferase (p < 0.001) immunopositive neuronal populations in the basal ganglia ... ). Thus, HIV-1 Vpr caused neuronal death through convergent pathogenic mechanisms ...
- alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based mo
Proc Natl Acad Sci U S A
Aug 07, 2002
... loss of substantia nigra dopaminergic neurons and the presence of cytoplasmic ... selective loss of nigral dopaminergic neurons associated with a dopaminergic denervation ... of human alpha-syn. This neuronal degeneration correlates with the appearance ...
- Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway
J Clin Invest
Dec 14, 2007
... the growth and repair of neuronal tissue, although the precise mechanisms ... was markedly upregulated in both neurons and endothelial cells. SN-mediated ... that SN acts directly on neurons after hypoxia and ischemic insult ...
- HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced
Proc Natl Acad Sci U S A
May 05, 2004
... been implicated as inducers of neuronal cell apoptosis. It is unclear ... more important in this process. Neuronal cells were treated with media ... virions did not. In contrast, neurons treated with media from infected ... prime candidates for contributing to neuronal apoptosis. Gene-array analyses also ...
- Constitutive NF-kappa B activity in neurons.
Mol Cell Biol
Jun 24, 1994
... NF-kappa B activity in neurons. Primary neuronal cultures derived from rat ... cultured neurons. NF-kappa B was also constitutively active in neurons in ... highly enriched in fractions containing neuronal nuclei prepared from rat cerebral ... reflect a distinct state of neuronal activity or differentiation. Furthermore, it ...
- SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons.
Mar 17, 2011
... optimize alertness and attention. These neurons, however, evidence heightened vulnerability to ... neurons, including the orexinergic, locus ceruleus, mesopontine cholinergic, and dopaminergic wake neurons ... of SIRT1 in wake-active neurons, temporally coinciding with lipofuscin accumulation ...
- Neurobehavioral performance in feline immunodeficiency virus infection: integrated analysis of viral burden, neuroinflammation, and neuronal injury in cortex.
Jul 02, 2009
... increased gliosis and reduced cortical neuronal counts (p < 0.05). The ... with viral burden, neuroinflammation, and neuronal loss.
- Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral
May 27, 2003
... between HIV-1 infection and neuronal death, we examined the neurotoxic ... neuronal death, with apoptosis representing 30 to 80% of the total neuron ...
- CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Apr 21, 2009
... ). Herein, we investigated CXCR3-mediated neuronal injury, particularly, its contribution to ... diminished neuroinflammation with preservation of neuronal autophagy by regulating CXCR3 activation ... activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral ...
- Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells.
May 18, 2009
... sensory neurons showing voltage-gated sodium channels. Some of the neurons displayed abundant active TRPV1 and TRPA1 receptors. Such functional neurons ... . E., Bennett, D. C. Functional neurons and melanocytes induced from immortal ...
- Memantine protects hippocampal neuronal function in murine human immunodeficienc
Aug 12, 2004
... animals. Immunocytochemical measures of neuronal antigens mirrored the neuronal physiological tests. These ...
- Interferon-alpha causes neuronal dysfunction in encephalitis.
Mar 26, 2009
... mice. Furthermore, treatment of primary neuron cultures with IFNalpha resulted in ... is involved in IFNalpha-mediated neuronal damage. These results show that ...
- Fractalkine and fractalkine receptors in human neurons and glial cells.
J Neurosci Res
Jul 18, 2002
... secretion in neurons was determined in A1 human hybrid neuronal cell line produced between a human cerebral neuron and a human neuroblastoma cell. Human neurons and astrocytes ... by CNS neurons and astrocytes produce biological effects in neurons and microglia ...
- Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive inte
Nov 10, 1988
... , we now suggest that the neuronal deficits associated with HIV may ... that VIP is important for neuronal survival in cell culture. Here ... potent in specifically producing significant neuronal cell death in dissociated hippocampal ...
- Regulation of neuronal P53 activity by CXCR 4.
Mol Cell Neurosci
Aug 15, 2005
... /infectious states may lead to neuronal dysfunction or damage. The major ... -dependent survival pathways in primary neurons. Neurons were stimulated with the HIV ... promote neuronal survival, increases p53 acetylation and p21 expression in neurons. Thus ... of CXCR 4 activation on neuronal survival in neuro-inflammatory disorders ...
- Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS.
Oct 24, 2011
... principally detected in macrophages, while neurons showed induction of proteinase-activated ... proteinase-activated receptor-1 in neurons. Exposure of feline immunodeficiency virus ... 占?contributed to dorsal root ganglion neuronal damage during lentivirus infections leading ...
- Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal in
J Clin Invest
Aug 19, 2005
... activation and progression of CNS neuronal injury in a CD8 lymphocyte ... monkeys. We found early, consistent neuronal injury coincident with viremia and ... rapid, near-complete reversal of neuronal injury. Robust macrophage accumulation and ...
- Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during H
J Leukoc Biol
Sep 15, 2000
... , blood-brain barrier (BBB) and neuronal dysfunction during HIV-1-associated ... with HIVE. Chemokines can damage neurons directly. Toxicity caused by binding ... -1alpha to its receptor on neurons exemplifies such mechanism. In toto ...
- TNF-related apoptosis-inducing ligand (TRAIL) induces neuronal apoptosis in HIV-encephalop
J Med Dent Sci
Apr 28, 2003
... (HIV)-encephalopathy. Extensive apoptosis of neurons is probably involved in the ... to investigate the mechanism of neuronal apoptosis. For this purpose, we ... - and -8-positive cells, including neurons, were found in the perivascular ... to cultured mouse primary neurons/glia resulted in neuronal apoptosis. Our results ...
- Neuronal loss in the frontal cortex in HIV infection.
Jun 11, 1991
... infection, we have quantitatively assessed neuronal populations, by means of a ... minimal changes. We compared their neuronal counts with those of eight ... affect the cerebral hemispheres). The neuronal numerical density was significantly lower ... HIV subgroups, which suggests that neuronal loss occurs in cases of ...
- Mechanisms of Neuronal Injury and Death in HIV-1 Associated Dementia.
Curr HIV Res
Jul 17, 2006
... downstream signaling pathways and disturb neuronal and glial function. Although there ... injurious mechanisms potentially contributing to neuronal death in association with HIV ...
- HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspas
Feb 04, 1999
... in cultured embryonic rat hippocampal neurons. Tat induced caspase activation, and ... peroxynitrite scavenger uric acid, protected neurons against Tat-induced apoptosis, indicating ... may prove beneficial in preventing neuronal degeneration and associated dementia in ...
- Detection of a neuron-specific 9.0-kb transcript which shares homology with antisense tran
Am J Pathol
Feb 19, 1993
... patients with AIDS, infection of neuronal cells by HIV-1 has ... detectable hybridization was observed to neuronal cells when the antisense probe ... , specific hybridization was observed to neuronal cells when the control sense ... this transcript is expressed in neuronal cells of both HIV-1 ...
- Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia:
Jul 08, 2005
... and is characterized by sensory neuronal injury accompanied by inflammation, which ... ganglia (DRG) cultures, consisting of neurons, Schwann cells, and macrophages. FIV ... macrophages accompanied by neuronal injury, indicated by neurite retraction, neuronal loss and ...
- Neuronal apoptotoic signaling pathways probed and intervened by chemically engineered SMM-
J Biol Chem
Jan 12, 2007
... contributes to HAD by causing neuronal damage and death, either directly ... CXCR4 or CCR5 signaling in neuronal apoptosis associated with HAD, we ... SMM-chemokines prevent or promote neuronal apoptosis. We show that inherently ... , can be modified to protect neurons from apoptosis induced by CXCR4 ...
- Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra i
Jan 09, 2008
... the progressive loss of dopaminergic neurons in the substantia nigra. The ... and protected primary mesencephalic dopaminergic neurons and their neurites against 1 ... cell-permeable Hsp70 protected dopaminergic neurons of the substantia nigra pars ... applied Tat-Hsp70 effectively prevents neuronal cell death in in vitro ...
- HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically c
Cell Death Differ
Jul 14, 2006
... and leads to neuronal cell death. Using mixed neuronal/glial cultures from ... . Moreover, these CCR5 ligands prevent neuronal cell death induced by stromal ... -1, a CXCR4 agonist. Both neurons and glia coexpress CXCR4 and ... that CCR5 ligands can protect neurons at least, in part, by ...
- Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosge
Jun 21, 2006
... ), caused increased neurotoxicity in human neuronal cultures with ApoE4 allele. Microarray ... cultures of ApoE3 and 4 neurons upon treatment with Tat + morphine ... function and exposure of the neurons to Tat + morphine. Using this ...
- Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Aug 06, 1992
... /motor complex may stem from neuronal injury mediated by the HIV ... necessary for gp120 to induce neuronal damage. We studied memantine, a ... protective effects from gp120-induced neuronal injury. In identified rat retinal ... NMDA antagonist capable of ameliorating neuronal damage associated with gp120.
- Decreased number of oxytocin neurons in the paraventricular nucleus of the human hypothala
Sep 21, 1993
... vasopressin (AVP) and oxytocin (OXT) neurons was determined morphometrically in the ... . The number of OXT-expressing neurons in the paraventricular nucleus of ... the number of AVP-expressing neurons in the paraventricular nucleus. Since ... selective changes in the OXT neurons of the paraventricular nucleus may ...
- Specific Role of VTA Dopamine Neuronal Firing Rates and Morphology in the Reversal of Anxiety-Related, but not Depression-Related Behavior in the Clock?19 Mouse Model of Mania.
Mar 24, 2011
... cell volume changes in dopamine neurons, which are also rescued by ... neurons in manic-like behavior, we manipulated the excitability of these neurons ... the firing rate of dopamine neurons in Clock?19 mice and ...
- Mechanisms of HIV-tat-Induced Phosphorylation of N-Methyl-D-Aspartate Receptor Subunit 2A in Human Primary Neurons. Implications for NeuroAIDS Pathogenesis.
Am J Pathol
May 07, 2010
... no evidence of HIV-infected neurons. Neuronal damage and dropout must therefore ... phosphorylation, which may lead to neuronal dysfunction and apoptosis in pathological ... are phosphorylated. Tat treatment of neuronal cultures enhanced phosphorylation of NR2A ...
- Cross talk between growth factors and viral and cellular factors alters neuronal signaling
Brain Res Brain Res Rev
Nov 18, 2005
... and neurons. Lack of a productive HIV-1 infection of neuronal cells ... determine the brain pathology and neuronal dysfunction seen in AIDS patients ... mechanisms of HIV-1-induced neuronal dysfunction by highlighting the interplay ... factors and their consequences in neuronal cell function.
- Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment an
Feb 24, 2000
... that mediate inflammation, dysfunction, and neuronal apoptosis. Neurologic disease is correlated ... colocalizes with glutamate in these neurons. Similar findings are observed in ... , and is neuroprotective to cultured neurons when coadministered with either the ...
- Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Nov 06, 1997
... genes in vivo into adult neurons. These data demonstrate the potential ...
- Development of a human neuronal cell model for human immunodeficiency virus (HIV
Aug 20, 2002
... macrophages (HIV/macrophage-induced neurotoxicity). Neuronal apoptosis may result from activation ... in primary neurons. We then established stable NT2.N neuronal lines that ... /macrophage-induced neuronal apoptosis, and Bcl-2 family proteins protect neurons against ...
- Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery.
Sep 09, 2009
... sized neurons (< 700 um2), predominantly colocalized with markers of nociceptive neurons, and ... colocalization with nociceptive neurons. Intrathecal administration also transduced DRG neurons at cervical ... to deliver transgenes to nociceptive neurons in mice. Furthermore, the characterization ...
- Spatial firing patterns of auditory neuron network modelling by computer simulation.
Sep 17, 1979
... at excitatory neurons' level i.e. the membrane potential of neuron soma. It is restricted to spatial patterns of the auditory neuron ... of auditory neurons aids in producing a sharpening in the neuron of ... two dimensional neuron networks may be expanded to three dimensional neuron networks ...
- Basic module for an adaptive control system based on neurone information process
J Biomed Eng
Jun 09, 1988
... the information processing capabilities of neurones. Neurones are now known to be ... these features in a neurone model. A single neuronal input system, the ... the glutamate receptor. A whole neurone with ten glutamate receptor regions ... neurone should be capable of recognizing patterns of inputs. As the neurone ...
- CXCR7 Protein Expression in Human Adult Brain and Differentiated Neurons.
Jun 09, 2011
... neurons, we studied CXCR7 protein expression in human brain and cultured neurons ... protein expression in human adult neurons, under normal and pathological conditions ... protein expression is found on neuronal plasma membrane. Interestingly, specific CXCR7 ... (pERK/pAkt) in rat cortical neurons. Neuronal CXCR7 co-localizes to some ...
- Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual.
Sep 23, 2003
... range and productive infection of neurons has never been demonstrated. Patient ... , enlarged granule cell neurons identified by the neuronal markers MAP-2 and ... polyomaviruses, in these granule cell neurons. In addition, JCV DNA was ... demonstrated that many granule cell neurons were infected with JCV but ...
- Evidence of neuronal degeneration in C57B1/6 mice infected with the LP-BM5 leukemia retrov
Mol Chem Neuropathol
Jul 26, 1999
... may incur neuronal damage. Although the number of neocortical neurons was unchanged ... number of striatal neurons decreased 19%. The remaining neurons were smaller, with ... in these mice, whereas striatal neurons degenerate. These concurrent degenerative and ...
- Classification of HIV-1-mediated neuronal dendritic and synaptic damage using multiple cri
Sep 14, 2004
... glutamate-mediated individual neuronal damage in cultured cortical neurons. Changes in the ... classify such HIV-1-mediated neuronal dendritic and synaptic damages. Given ... order to gain insight about neuronal dendritic damages. This knowledge can ... the prevention or reversal of neuronal damage associated with HAD. Finally ...
- Neuronal PINCH is Regulated by TNF-alpha and is Required for Neurite Extension.
J Neuroimmune Pharmacol
Aug 06, 2010
... -rich protein (PINCH), in the neurons of HIV patients' brains, compared ... ), suggesting PINCH's involvement in neuronal signaling during HIV infection of ... CNS was utilized. We investigated neuronal PINCH expression, subcellular distribution, and ... . Our results indicate that in neurons, TNF-alpha stimulation increases PINCH ...
- Automated image analysis for counting unstained cultured neurones.
J Neurosci Methods
Aug 08, 1991
... of live or fixed, unstained neurones present in a representative region ... dish containing cultured mouse hippocampal neurones was placed on the motorized ... an inverted microscope, and the neurones were visualized using Hoffman modulation ... found to have significantly fewer neurones than the six control dishes ...
- Silencing the PTEN gene is protective against neuronal death induced by human immunodefici
May 16, 2007
Neurons are targets of toxicity induced ... [Ca(2+)](i) in striatal neurons and activates multiple cell death ... promotes proliferation and survival. Striatal neurons were nucleofected with short interfering ... of neurons transfected with control construct by 72 h, PTEN-silenced neurons ...
- HIV-related neuromuscular syndrome simulating motor neuron disease.
Apr 17, 1990
... with clinical diagnosis of motor neuron disease. The patient died from ...
- Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.
Apr 28, 2009
... matter suggests that HIV causes neuronal dysfunction soon after infection, which ...
- Lower motor neuron dysfunction associated with human immunodeficiency virus infection.
Jan 10, 1994
... a clinical picture of motor neuron disease is uncommon, with three ... -infected patient with apparent motor neuron disease. DESIGN: Single patient case ... case demonstrates a progressive motor neuron dysfunction in a patient positive ... differential diagnosis of apparent motor neuron disease.
- [Motor neuron disease and HIV]
May 30, 1997
Motor-neuron disease, in particular its commonest ... clinical condition compatible with motor-neuron disease 18 months after diagnosis ... necessary for diagnosis of motor-neurone disease and for exclusion of ... case of ELA type motor neurone disease with no further HIV ...
- TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-as
Feb 20, 2004
... receptors and cell types including neurons. In this report, TRAIL protein ... positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons ... a dose-dependent effect on neuronal apoptosis. These results support a ...
- Increased density of neurons containing NADPH diaphorase and nitric oxide synthase in the
Jul 28, 2006
... (NDP) co-containing cerebrocortical neurons (NOSN) neurons are affected in patients infected ... induces NOS expression powerfully in neurons that normally do not synthesize ... of NOS-containing local circuit neurons in patients with HIV-1 ...
- HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization.
Nov 14, 2008
... in cortical neurons, thus compromising the ability of the neuron to buffer ... of the ER in cortical neurons in vitro. RyR antagonism attenuated ... abnormal RyR signaling mediates the neuronal UPR with failure of mitochondrial ...
- Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
Am J Transl Res
Dec 07, 2009
... works have associated inflammation and neuronal loss with cognitive deficits inherent ... to modulate GFAP expression and neuronal loss in an HIV-1 ... staining and significant reduction in neuronal loss through apoptosis as demonstrated ... GFAP and associated astrocytosis and neuronal loss.
- Lewy bodies in the lateral hypothalamus: do they imply neuronal loss?
Sep 02, 1993
... presence of Lewy bodies indicated neuronal loss. Most Lewy bodies were ... patients. The number of NTL neurons in the PD patients was ... , did not seem depleted in neuronal numbers, although occasional neuronophagia was ...
- [Calcium, neuronal death and neurological disease]
Jan 03, 1997
... , or neuronal plasticity, etc. However, its excessive influx to neurons due to ... events which causes cytotoxicity and neuronal death. Ca2+ mediated toxicity has ...
- Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum
Magn Reson Med
Feb 28, 2008
... that both excitatory and inhibitory neurons are affected. Highly significant correlations ... GABA/Cr were observed. These neuronal metabolites were also decreased in ... would be insufficient to prevent neuronal injury. Magn Reson Med 59 ...
- Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer.
Genet Vaccines Ther
Jan 15, 2009
... peripheral muscle to spinal motor neurons (MNs) was previously reported. Despite ... possessed the best performance and neuronal tropism among the vectors tested ... in the treatment of motor neuron diseases (MND), pain, and neuropathy ...
- Recombinant nef HIV-IIIB protein is toxic to human neurons in culture.
Jul 03, 2000
... HIV infected human brains with neuronal damage [A. Ranki, M. Nyberg ... -N-SH neuroblastoma, primary human neurons and glial cells were exposed ... nef and TNFalpha compromise human neurons in culture. Thus, like other ... nef may also contribute to neuronal damage that has been reported ...
- Effects of putative neurotransmitters on sympathetic preganglionic neurons.
Annu Rev Physiol
Jul 14, 1988
... P, glutamate, and 5-HT neurons all abolish sympathetic activity and ... pathway from brain stem sympathetic neurons to the IML. For example ...
- Communication aids in patients with motor neurone disease.
Br Med J (Clin Res Ed)
Aug 10, 1981
... and communication problems in motor neurone disease to try to assess ... . Sixteen patients suffering from motor neurone disease with communication problems had ...
- Neuronal substrates for SIV encephalopathy.
Apr 06, 1995
... that neuronal dysfunction discernable as altered neuropeptide expression in cortical neurons precedes ...
- Cellular aspects of HIV-1 infection of macrophages leading to neuronal dysfunction in in v
J Leukoc Biol
Aug 07, 1997
... encephalitis. The final outcome regarding neuronal function and cell loss is ... factors that might lead to neuronal injury in in vitro model ...
- [Experimental study of mechanisms of neuronal death in the course oh HIV infecti
Bull Acad Natl Med
Oct 02, 1997
... gp120 are toxic for human neurones in vitro. This neurotoxicity is ... interaction of gp120 with the neuronal membrane which leads to perturbations ...
- Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1/gp120-ind
Crit Rev Neurobiol
Dec 07, 2004
... the agents causing neuronal cell death. Gp120 causes neuronal cell death both ...
- Lentiviral Delivery of RNAi in Hippocampal Neurons.
Feb 13, 2006
... precursor of siRNA, into primary neurons to suppress gene expression. Major ... , transduction of dissociated primary hippocampal neurons, and testing the effectiveness of ...