HIV-AIDS and HIV research citations
Annotated publication timeline
x-axis represents time, y-axis represents article importance (citation-based)
- Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
Ann Intern Med
Jun 29, 2000
... with protease inhibitors has transformed HIV infection from a terminal condition ... . DESIGN: Prospective, observational study. SETTING: HIV clinics in a Veterans Affairs ... university medical center. PATIENTS: 99 HIV-infected patients who were prescribed ... virologic outcome for patients with HIV infection. Diagnosis and treatment of ...
- Antiretroviral-drug resistance among patients recently infected with HIV.
N Engl J Med
Aug 08, 2002
... with the human immunodeficiency virus (HIV), the prevalence of transmitted resistance ... and drug-resistance mutations in HIV in plasma samples from 377 subjects with primary HIV infection who had not yet ... ). CONCLUSIONS: The proportion of new HIV infections that involve drug-resistant ...
- Immune control of HIV-1 after early treatment of acute infection.
Oct 11, 2000
... infections. Successful treatment of acute HIV-1 infection leads to augmentation ... exceeded 5,000 copies of HIV-1 RNA per millilitre of ... provide rationale for immunotherapy in HIV-1 infection.
- Identification of a major co-receptor for primary isolates of HIV-1.
Jul 25, 1996
Entry of HIV-1 into target cells requires ... primary macrophage-tropic strains of HIV-1 is CC-CKR-5 ...
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
Feb 03, 1995
... virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease ... rise substantially. Minimum estimates of HIV-1 production and clearance and ... turnover indicate that replication of HIV-1 in vivo is continuous ...
- Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.
Annu Rev Immunol
Aug 31, 1999
... CD4, the human immunodeficiency virus (HIV) requires a coreceptor for entry ... line-tropic and macrophage-tropic HIV-1 isolates, respectively. The updated ... perspectives on central puzzles of HIV-1 disease, including the selective ... perspectives on fundamental aspects of HIV-1 transmission and pathogenesis, the ...
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled
Jun 27, 1996
A cofactor for HIV-1 (human immunodeficiency virus-type ... nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin ... messenger RNA levels correlated with HIV-1 permissiveness in diverse human ...
- Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Dec 16, 1997
... human immunodeficiency virus-type 1 (HIV-1) infection. In individuals who ... therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell ... . In persons with chronic infection, HIV-1-specific proliferative responses to ... related to viral load. Strong HIV-1-specific proliferative responses were ...
- The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.
Jul 03, 2003
... human immunodeficiency virus type 1 (HIV-1) replication, is a cytidine ... can be counteracted by the HIV-1 virion infectivity factor (Vif ...
- Skewed maturation of memory HIV-specific CD8 T lymphocytes.
Mar 12, 2001
... and antiviral immune responses to HIV and cytomegalovirus. Ex vivo analysis ... populations, identified four subsets of HIV- and CMV-specific CD8+ T ... distribution of these populations in HIV- and CMV-specific CD8+ T ... demonstrate a skewed maturation of HIV-specific memory CD8+ T cells ...
- Changes in thymic function with age and during the treatment of HIV infection.
Jan 19, 1999
... antigens that are lost during HIV infection; this effect has been ... and bone-marrow transplantation. Adult HIV-infected patients treated with highly ... is maintained into late adulthood. HIV infection leads to a decrease ...
- Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, e
May 19, 1999
Combination therapy for HIV-1 infection can reduce plasma ... might eradicate the infection. However, HIV-1 can persist in a ... mechanism for lifelong persistence of HIV-1, even in patients on ...
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Aug 14, 1996
... facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected ... variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein ...
- Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif
Aug 08, 2002
... notably human immunodeficiency virus-1 (HIV-1). These proteins are potent ... for pathogenic infections in vivo. HIV-1 Vif seems to be ... regulatory circuit is critical for HIV-1 replication, perturbing the circuit ... a promising target for future HIV/AIDS therapies.
- HIV preferentially infects HIV-specific CD4+ T cells.
May 02, 2002
... cells, at all stages of HIV disease. Additionally, following viral rebound ... , the frequency of HIV viral DNA in the HIV-specific pool of ... specificities. These findings show that HIV-specific CD4(+) T cells are ... loss of immunological control of HIV replication. Furthermore, the phenomenon of ...
- Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed ind
Sep 26, 1996
... have been multiply exposed to HIV-1 but remain uninfected. The ... recently described coreceptor for primary HIV-1 isolates. These individuals appear ... individuals from sexual transmission of HIV-1. Heterozygous individuals are quite ... importance of CKR-5 in HIV-1 transmission and suggest that ...
- Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infect
N Engl J Med
Jul 29, 2004
... with the human immunodeficiency virus (HIV). We compared the efficacy and ... who were also infected with HIV. METHODS: A total of 868 ... who were infected with both HIV and HCV and who had ... : Among patients infected with both HIV and HCV, the combination of ...
- Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therap
Dec 02, 1997
... human immunodeficiency virus-type 1 (HIV-1) in patients on highly ... CD4+ T cells harboring latent HIV-1 was low, 0.2 ...
- HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generati
Apr 25, 1996
... human immunodeficiency virus-type 1 (HIV-1) viral load data collected ... of a potent inhibitor of HIV-1 protease. Productively infected cells ... average, and that the average HIV-1 generation time--defined as ... only a kinetic picture of HIV-1 pathogenesis, but also theoretical ...
- The growing burden of tuberculosis: global trends and interactions with the HIV epidemic.
Arch Intern Med
May 13, 2003
... linked to human immunodeficiency virus (HIV) infection. METHODS: We reviewed data ... Joint United Nations Programme on HIV/Acquired Immunodeficiency Syndrome (UNAIDS), the ... million coinfected adults. CONCLUSIONS: The HIV pandemic presents a massive challenge ...
- Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the Internati
Jul 03, 1997
... therapy for human immunodeficiency virus (HIV) disease. PARTICIPANTS: The original International ... and care of patients with HIV infection. EVIDENCE: The following were ... international research conferences; studies of HIV pathophysiology; and expert opinions of ...
- The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.
Nov 03, 2003
... . Here we show that the HIV-1 virion infectivity factor (Vif ... aimed at stabilizing APOBEC3G in HIV-1 infected cells should be ...
- Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors
Jan 22, 1996
... control of human immunodeficiency virus (HIV) infection in vivo, either by ... by the release of HIV-suppressive factors (HIV-SF). The chemokines RANTES ... and primary CD8+ T cells. HIV-SF activity produced by these ... inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency ...
- HIV-1 genome nuclear import is mediated by a central DNA flap.
May 05, 2000
HIV-1 and other lentiviruses have ... of the host cell. In HIV-1 reverse transcription, a central ... as a cis-determinant of HIV-1 DNA nuclear import. Wild ... of the nuclear membrane. Consistently, HIV-1 vectors devoid of DNA ...
- HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection
May 19, 1999
... + T-cell responses in controlling HIV-1 infection remains unclear. Previous ... contribute to host defense against HIV-1. Here, using flow cytometric ... most subjects with active/progressive HIV-1 infection (median frequency, 0 ... immunologic participation in long-term HIV-1 control will probably require ...
- The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Mar 21, 1997
... used by distinct strains of HIV-1 as cofactors for viral ... fusin), whereas macrophage-tropic primary HIV-1 isolates use CCR-5 ... a biological ligand for the HIV-1 entry cofactor LESTR, we tested whether it inhibited HIV-1. SDF-1 inhibited infection by T-tropic HIV-1 of HeLa-CD4 cells ...
- The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Feb 26, 2004
... . Human immunodeficiency virus type 1 (HIV-1), the cause of acquired ... restriction acts on the incoming HIV-1 capsid and is mediated ... bodies, as the blocking factor. HIV-1 infection is restricted more ... TRIM5alpha-mediated block than is HIV-1, and this difference in ...
- Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5
Sep 23, 1996
... for macrophage-tropic (M-tropic) HIV-1 strains, and the orphan ... by macrophage- and dual-tropic HIV-1 strains. In a cohort of HIV-1 infected caucasian subjects, no ... to infection by M-tropic HIV-1 viruses, confirming that CCR ... major co-receptor for primary HIV-1 strains. The lower frequency ...
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained
Oct 30, 2002
... unclear why immunological control of HIV replication is incomplete in most ... CD8+ T cell response to HIV-infected CD4+ T cells in ... immunological control of HIV. Although high frequencies of HIV-specific CD8+ T ... by increased proliferative capacity of HIV-specific CD8+ T cells linked ...
- Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implic
Dec 14, 1998
... human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase with a ...
- Quantifying residual HIV-1 replication in patients receiving combination antiretroviral th
N Engl J Med
May 27, 1999
... human immunodeficiency virus type 1 (HIV-1), combination antiretroviral therapy can ... whether antiviral treatment can eradicate HIV-1. METHODS: We looked for ... decrease of latent, replication-competent HIV-1 in resting CD4 lymphocytes ... that combination antiretroviral regimens suppress HIV-1 replication in some but ...
- Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neu
Jul 01, 1998
... entry of human immunodeficiency virus (HIV) into cells requires the sequential ... can elicit virus-neutralizing antibodies, HIV eludes the immune system. We ... .5 A resolution of an HIV-1 gp120 core complexed with ... understanding the complex biology of HIV entry into cells and should ...
- Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
Dec 02, 1997
... treatment of human immunodeficiency virus (HIV) disease, it is important to ... the suppression of their plasma HIV RNA to fewer than 50 ... 2 years. Partial sequencing of HIV pol revealed no new drug ...
- Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants o
Jan 25, 2002
BACKGROUND:HIV-1-infected patients vary considerably ... expression, CD4-cell count, and HIV-1 viraemia. FINDINGS: Median drug ...
- Prognosis in HIV-1 infection predicted by the quantity of virus in plasma.
Jul 05, 1996
... human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was ...
- Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial.
Aug 03, 1999
BACKGROUND: Growing evidence has linked HIV-1 resistance mutations and drug ... , open, randomised, controlled study of HIV-1-infected patients in whom ... endpoint was the change in HIV-1 RNA viral load. Analysis ... (214/microL [SD14]) and log HIV-1 RNA viral load at ...
- HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.
Nov 03, 2003
... infectivity factor (Vif) encoded by HIV-1 neutralizes a potent antiviral ... , this antiviral pathway efficiently inactivates HIV-1. It was recently reported ... and preventing its incorporation into HIV-1 virions. Studies of Vif ...
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5
Aug 14, 1996
... a cofactor for M-tropic HIV viruses. Expression of CKR-5 ... -tropic, but not T-tropic, HIV-1 env proteins. Expression of ... strain. A dual-tropic primary HIV-1 isolate (89.6) utilizes ... -3 and CKR-2b support HIV-1 89.6 env-mediated ...
- Change in coreceptor use coreceptor use correlates with disease progression in HIV-1--infe
J Exp Med
Mar 14, 1997
... Human Immunodeficiency Virus type 1 (HIV-1) into CD4+ cells. One ... (NSI), macrophage-tropic strains of HIV-1, while another, fusin or ... . Using sequential primary isolates of HIV-1, we examined whether viruses ... counts. These results suggest that HIV-1 evolves during the course ...
- Antibody neutralization and escape by HIV-1.
Mar 20, 2003
... plasma from patients with acute HIV infection. Here we report the ... 52 days after detection of HIV-specific antibodies. The viral inhibitory ... , and the exceptional density of HIV-1 envelope glycosylation generally, led ... a new mechanism contributing to HIV-1 persistence in the face ...
- HIV-1 integration in the human genome favors active genes and local hotspots.
Aug 30, 2002
A defining feature of HIV replication is integration of the ... mapping of 524 sites of HIV cDNA integration on the human ... in cells after infection by HIV-1. Regional hotspots for integration ... how selective targeting promotes aggressive HIV replication.
- Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
Oct 11, 2001
Like other enveloped viruses, HIV-1 uses cellular machinery to ... sorting (Vps), is required for HIV-1 budding. The UEV domain ... by small interfering RNA arrests HIV-1 budding at a late ... vacuolar protein sorting also arrest HIV-1 and MLV budding. These ...
- Pathways to neuronal injury and apoptosis in HIV-associated dementia.
Apr 19, 2001
Human immunodeficiency virus-1 (HIV-1) can induce dementia with ... , but discovery in brain of HIV-1-binding sites (chemokine receptors) provides new insights. HIV-1 infects macrophages and microglia ...
- Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection.
Ann Intern Med
Jun 12, 1997
... . PATIENTS: 1604 men infected with HIV-1. MEASUREMENTS: The markers compared ... categories were defined by plasma HIV-1 RNA concentrations: 500 copies ... . A regression tree incorporating both HIV-1 RNA measurements and CD4 ... death, but the prognosis of HIV-infected persons is more accurately ...
- Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-med
Nov 30, 1998
... the transmembrane subunit of the HIV-1 envelope protein, blocks cell ... , dose-related declines in plasma HIV RNA in all subjects who ... log10 median decline in plasma HIV RNA in these subjects. This ... and provides potent inhibition of HIV replication comparable to anti-retroviral ...
- Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric vir
Feb 17, 2000
... the human immunodeficiency virus-1 (HIV-1)/simian immunodeficiency virus (SIV ... in vivo evaluation of anti-HIV-1 envelope glycoprotein immune responses ... against an intravenous challenge. However, HIV-1 is most often transmitted ... estrous cycle with progesterone, anti-HIV-1 neutralizing monoclonal antibodies 2F5 ...
- Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinica
Mar 09, 2000
... precisely defined. Whether breast milk HIV-1 transmission risk exceeds the ... 24 months. PARTICIPANTS: Of 425 HIV-1-seropositive, antiretroviral-naive pregnant ... = 213). MAIN OUTCOME MEASURES: Infant HIV-1 infection and death during ... point. The cumulative probability of HIV-1 infection at 24 months ...
- Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients recei
N Engl J Med
May 27, 1999
... (mRNA) that are essential for HIV-1 replication. Approximately every 6 ... levels of cell-associated unintegrated HIV-1 DNA and unspliced viral ... cell-associated integrated and unintegrated HIV-1 DNA and mRNA occurred ... therapy, these findings suggest that HIV-1 infection cannot be eradicated ...
- Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.
Jul 15, 2003
... that prevents its virion encapsidation. HIV-1 Vif did not efficiently ... of human APOBEC3G encapsidated in HIV-1 virions but did not ... potent inhibitors of wild-type HIV-1 replication. The species-specificity ... play a role in restricting HIV-1 infection to humans. Together ...
- Atomic structure of the ectodomain from HIV-1 gp41.
Jun 09, 1997
... gp120/gp41 effects entry of HIV-1 into the cell. The ...
- CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
Mar 03, 1997
... CCR5 alleles exhibit resistance to HIV-1 infection, suggesting that CCR5 ... vivo contribution of CCR3 to HIV-1 infection and pathogenesis is unknown. HIV-1 infects the central nervous ... an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as ...
- HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
Apr 01, 1999
... human immunodeficiency virus-type 1 (HIV-1), whereas individuals who were ... 28 to 40 percent of HIV-1-infected Caucasian patients who ...
- The challenge of viral reservoirs in HIV-1 infection.
Annu Rev Med
Jan 30, 2002
... reservoirs for HIV-1. It is now clear that HIV-1 persists ... to guarantee lifetime persistence of HIV-1 in the majority of ... implications of this and other HIV-1 reservoirs are discussed.
- The Serostatus Approach to Fighting the HIV Epidemic: prevention strategies for infected i
Am J Public Health
Jul 09, 2001
... programs, especially for individuals with HIV, to reduce the risk of ... the virus. For individuals with HIV, SAFE comprises action steps that focus on diagnosing all HIV-infected persons, linking them to ... them in adopting and sustaining HIV risk reduction behavior. SAFE couple ...
- Decay characteristics of HIV-1-infected compartments during combination therapy.
May 28, 1997
... virus type 1 (HIV-1). The concentration of HIV-1 in plasma ... to eliminate HIV-1 from these compartments. To eradicate HIV-1 completely ...
- The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway
Sep 14, 1995
HIV-1 Rev protein directs nuclear ...
- The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.
Mar 03, 1988
... human immunodeficiency virus type 1 (HIV-1) is frequently complicated in ... is not well understood. Productive HIV-1 brain infection is detected ... of the nervous system to HIV-1 and chronic leptomeningeal infection ... of immunosuppression, genetic changes in HIV-1 may underlie the neuropathological ...
- A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its h
Mar 19, 1998
The HIV-1 Tat protein regulates transcription ...
- Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary
Feb 28, 1997
The HIV-1-specific cytotoxic T lymphocyte ( ... decline in viremia during primary HIV-1 infection, but definitive evidence ... in vivo. One aim of HIV-1 vaccines should thus be ...
- Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.
May 28, 1997
The capacity of HIV-1 to establish latent infection ... infected cells all suggest that HIV-1 replication continues throughout the ... ). The most prevalent form of HIV-1 DNA in resting and ... in the lymphoid tissues integrated HIV-1 DNA is present in ...
- Core structure of gp41 from the HIV envelope glycoprotein.
May 15, 1997
... human immunodeficiency virus type 1 (HIV-1) consists of a complex ... of small-molecule inhibitors of HIV infection are directly suggested by ...
- Cellular immune responses to HIV.
Apr 19, 2001
- Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV
Jun 29, 2000
... transduce non-dividing cells. The HIV-1 proteins Matrix, Vpr and ...
- Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of
Oct 04, 1999
... 076 zidovudine prophylaxis regimen for HIV-1-infected pregnant women and ... a significant decrease in vertical HIV-1 transmission in non-breastfeeding ... by HIV-1 RNA PCR. We assessed HIV-1 transmission and HIV-1 ... : Nevirapine lowered the risk of HIV-1 transmission during the first ...
- The protein network of HIV budding.
Sep 24, 2003
... E proteins) also participate in HIV release, we identified 22 candidate ... E proteins were found in HIV-1 particles, and dominant-negative ... human class E proteins arrested HIV-1 budding through plasmal and ... participates in the release of HIV and probably many other viruses ...
- Hepatitis C and progression of HIV disease.
Jul 03, 2002
... progression of human immunodeficiency virus (HIV) disease. OBJECTIVE: To assess the ... clinical and immunologic progression of HIV disease and immunologic response to ... study. SETTING: University-based, urban HIV clinic in the United States ...
- Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients.
N Engl J Med
Mar 14, 2002
... the human immunodeficiency virus (HIV), 47 HIV-infected asymptomatic patients who had ... with antiretroviral drugs, and 8 HIV-infected patients who were receiving ... lower than those of non-HIV-infected controls and 43 percent lower than those of HIV-infected asymptomatic patients never treated ...
- In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.
May 04, 1995
... human immunodeficiency virus type 1 (HIV-1) protease have entered clinical ... agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse ...
- The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T l
Proc Natl Acad Sci U S A
Apr 07, 1997
... CCR5 function as coreceptors for HIV-1 entry into CD4+ cells. During the early stages of HIV infection, viral isolates tend to ... strains during the course of HIV infection.
- Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 in
Feb 23, 1998
... human immunodeficiency virus type-1 (HIV-1) infection is still controversial ...
- Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes.
Feb 25, 1999
... virus type 1 (HIV-1) and type 2 (HIV-2) represent cross ... . Although the primate reservoir of HIV-2 has been clearly identified ... origin of HIV-1 remains uncertain. Viruses related to HIV-1 have ... subspecies-specific) phylogenetic lineages. All HIV-1 strains known to infect ...
- Reactive oxygen intermediates as apparently widely used messengers in the activation of th
Aug 14, 1991
... the expression and replication of HIV-1 in a human T ...
- CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor C
Dec 10, 1996
... human immunodeficiency viruses type 1 (HIV-1) require particular chemokine receptors ... glycoprotein, of macrophage-tropic primary HIV-1 and soluble CD4 interacts ... V3 loop, which can specify HIV-1 tropism and chemokine receptor ... -5. These results suggest that HIV-1 attachment to CD4 creates ...
- Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.
Proc Natl Acad Sci U S A
May 17, 1999
... rates during untreated periods in HIV-1-infected individuals. This mutation ... approximately 17% in the non-HIV-1-infected Japanese population and ... influence on the incidence of HIV-1 infection. Functional analyses of ... mutation increases RANTES expression in HIV-1-infected individuals and thus ...
- The antigenic structure of the HIV gp120 envelope glycoprotein.
Jul 01, 1998
The human immunodeficiency virus HIV-1 establishes persistent infections in ... acquired immunodeficiency syndrome (AIDS). The HIV-1 envelope glycoproteins, gp120 and ... virus entry into target cells. HIV-1 entry depends on the ... basis for the ability of HIV-1 to evade the humoral ...
- The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.
Dec 03, 1996
... uninfected despite extensive exposure to HIV-1. This allele was found ... . To determine its role in HIV-1 transmission and disease progression ... genotype against sexual acquisition of HIV-1. No evidence was found ... that heterozygotes were protected against HIV-1 infection, but a limited ...
- A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients
Aug 04, 1998
... resistance in patients receiving potent HIV protease inhibitor therapy. DESIGN: Cross ... a university teaching hospital. PATIENTS: HIV-infected patients either receiving at ... load were also assessed. RESULTS: HIV protease inhibitor-naive patients had ... body composition to healthy men. HIV protease inhibitor therapy was associated ...
- The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protea
J Clin Invest
Feb 05, 1998
... agents in the therapy of HIV-1 infection. However, limited oral ... raises the possibility that higher HIV-1 protease inhibitor concentrations may ...
- Evolution and transmission of stable CTL escape mutations in HIV infection.
Jul 19, 2001
... evidence indicates that potent anti-HIV-1 activity is mediated by ... expressing HLA-B27 who transmit HIV-1 perinatally, we document transmission ... epitope and fail to contain HIV replication. These CTL escape variants ...
- Diversity of receptors binding HIV on dendritic cell subsets.
Sep 27, 2002
The ability of HIV-1 to use dendritic cells ( ... may be crucial in early HIV-1 pathogenesis. We have characterized ... of CLRs able to bind HIV-1 in skin DCs may ...
- HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-b
Dec 12, 2002
... ability of human immunodeficiency virus (HIV-1) to persist and cause ... found that it neutralized primary HIV-1 isolates with great potency ... most antibodies, conformational masking enables HIV-1 to maintain receptor binding ...
- Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell res
Nov 16, 2001
... because comprehensive analysis of total HIV-specific CD4(+) and CD8(+) T ... antiretroviral therapy na챦ve HIV-infected patients. HIV-specific CD8(+) T-cell ... % of total CD8(+) T cells. HIV-specific CD4(+) T-cell responses ... suggest that overall frequencies of HIV-specific T cells are not ...
- Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral t
Jun 26, 2001
... assessed. Blood analysis including plasma HIV-1 RNA CD4 cell counts ... clinical hepatitis was common in HIV-1-infected patients receiving nevirapine ...
- No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, p
Feb 13, 2004
... commonly complicates antiretroviral therapy of HIV-1 infection. Thiazolidinediones such as ... congenital lipodystrophy, and can prevent HIV-1 protease inhibitor toxicity to ... that rosiglitazone would improve HIV lipoatrophy. METHODS: 108 HIV-1-infected lipoatrophic ...
- HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocyt
Feb 13, 1998
... with the human immunodeficiency virus (HIV-1) develop AIDS. To resolve ... lysed primary cells infected with HIV-1 if the viral nef ... an excess of the relevant HIV-1 epitope as soluble peptide ... evasion of CTL lysis by HIV-1-infected cells.
- Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, rec
Proc Natl Acad Sci U S A
Dec 11, 2002
HIV entry inhibitors include coreceptor antagonists ...
- Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in
Jun 21, 2000
... suppression and antiretroviral resistance in HIV-infected homeless and marginally housed ... (SRO) hotels. PARTICIPANTS: Thirty-four HIV-infected people with a median ... , and self-report; HIV RNA viral load; and HIV-1 genotypic changes ... % of the variation in concurrent HIV RNA levels. The three adherence ...
- Host factors and the pathogenesis of HIV-induced disease.
Jan 07, 1997
... level of human immunodeficiency virus (HIV) replication in patients reflects a ... the cellular co-receptors for HIV and the cellular tropism of ... will advance our understanding of HIV-induced pathogenesis and suggests new ...
- Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
Feb 22, 1999
... controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model ... cell-mediated immunity in controlling HIV-1 infection and support the ...
- HIV-1 drug resistance in newly infected individuals.
Oct 04, 1999
... treat human immunodeficiency virus 1 (HIV-1) infection may result in ... performed. CONCLUSION: The prevalence of HIV-1 variants with known resistance ... immunological benefit when treating primary HIV-1 infection. Further efforts to ... of transmission of drug-resistant HIV-1 variants, particularly in cohorts ...
- Diversity considerations in HIV-1 vaccine selection.
Jun 28, 2002
... , human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and ... overly optimistic, however, given that HIV-1 envelope proteins can differ ...
- HIV chemotherapy.
Apr 19, 2001
... of the human immunodeficiency virus (HIV) has transformed the face of ... and healthcare utilization has diminished. HIV therapy has also provided many ... viral and cellular dynamics of HIV infection. But challenges remain. Treatment does not suppress HIV replication in all patients, and ...
- Variations in the care of HIV-infected adults in the United States: results from the HIV C
Jul 02, 1999
... infected with human immunodeficiency virus (HIV) receive adequate care. OBJECTIVE: To ... adult US population infected with HIV. DESIGN: Cohort study that consisted ... January 1998 conducted by the HIV Cost and Services Utilization Consortium ... Pneumocystis carinii pneumonia). RESULTS: Inadequate HIV care was commonly reported at ...
- Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Ab
Aug 31, 1999
... mother-to-child transmission of HIV-1 infection is high. Short ... of such a regimen among HIV-1-seropositive breastfeeding women in ... February, 1998, all consenting, eligible HIV-1-seropositive pregnant women attending ... identified as HIV-1 infected. The estimated risk of HIV-1 transmission ...
- Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepat
Dec 03, 2003
... ) has improved the prognosis of HIV infection. However, replication of hepatitis ... the effect of HAART in HIV/HCV-coinfected patients, we studied ...
- AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.
Sep 24, 2003
HIV-1 and other retroviruses exit ... in the p6 region of HIV-1 Gag mediates the detachment ... ) machinery. We now show that HIV Gag p6 contains a second ... in the L domain of HIV-1 p6 and EIAV p9 ...
- CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1
J Exp Med
Jun 02, 1997
... receptors serve as coreceptors for HIV entry into CD4+ cells. Their ... highly resistant to infection with HIV-1. In this study, CCR5 ... of chemokine binding, indicating that HIV-1 and ligands bind to ... feasibility of blocking macrophage-tropic HIV-1 entry into cells with ...
- Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial.
Aug 08, 2000
... majority of human immunodeficiency virus (HIV)-infected individuals who are treated ... the metabolic disturbances associated with HIV lipodystrophy syndrome. OBJECTIVE: To determine ... related cardiovascular risk parameters in HIV-infected patients with lipodystrophy. JAMA ...
- Human chemokines: an update.
Annu Rev Immunol
Jul 29, 1997
... that some chemokines function as HIV-suppressive factors by interacting with ... as the binding sites for HIV-1.
- Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The
Sep 02, 1999
... of protease inhibitors (PIs) to HIV-infected individuals has been associated ... levels were quantified in 93 HIV-infected adults receiving PIs. Comparison ... and with 28 nonPI-treated HIV-infected subjects. An elevation in ... . CONCLUSIONS: Administration of PIs to HIV-infected individuals is associated with ...