CD4-AIDS and HIV research citations
Annotated publication timeline
x-axis represents time, y-axis represents article importance (citation-based)
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
Feb 03, 1995
... .1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially ... production and clearance and of CD4 lymphocyte turnover indicate that replication ... , driving the rapid turnover of CD4 lymphocytes.
- Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Dec 16, 1997
Virus-specific CD4+ T helper lymphocytes are critical ... , and vigorous HIV-1-specific CD4+ T cell proliferative responses were ...
- Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, e
May 19, 1999
... a latent form in resting CD4+ T cells. We measured the ... . Thus, latent infection of resting CD4+ T cells provides a mechanism ...
- HIV preferentially infects HIV-specific CD4+ T cells.
May 02, 2002
... with the progressive loss of CD4(+) T cells through their destruction ... in particular whether HIV-specific CD4(+) T cells are preferentially affected ... show that HIV-specific memory CD4(+) T cells in infected individuals ... findings show that HIV-specific CD4(+) T cells are preferentially infected ...
- HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection
May 19, 1999
... role of HIV-1-specific CD4+ T-cell responses in controlling ... gag specific, T-helper-1 CD4+ memory T cells are detectable ... median frequencies of gag-specific CD4+ memory T cells: 0.08 ... . Thus, functional HIV-1-specific CD4+ T cells are commonly available ...
- Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and functio
Jul 21, 1997
... active antiretroviral therapy (HAART) increases CD4(+) cell numbers, but its ability ... activity together with an improved CD4(+) T cell reactivity to recall ... late rise of "na챦ve" CD4(+) lymphocytes while CD8(+) T cells ... reverse HIV-driven activation and CD4(+) T cell defects in advanced ...
- Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neu
Jul 01, 1998
... envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor ... two-domain fragment of human CD4 and an antigen-binding fragment ... structure reveals a cavity-laden CD4-gp120 interface, a conserved binding ... for a conformational change upon CD4 binding, the nature of a ...
- Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection.
Ann Intern Med
Jun 12, 1997
... ; number and percentage of CD3+, CD4+, and CD8+ lymphocytes; and plasma ... order of predictive strength) by CD4+ lymphocyte count and serum neopterin ... risk at all levels of CD4+ lymphocyte counts and predicted their ... HIV-1 RNA measurements and CD4+ lymphocyte counts provided better discrimination ...
- Rates of disease progression by baseline CD4 cell count and viral load after initiating tr
Nov 27, 2001
... antiretroviral therapy, stratified by baseline CD4 cell count and HIV RNA ... of acquired immunodeficiency syndrome (AIDS), CD4 cell count, use of protease ... by age or sex. Only CD4 cell count remained statistically significant ... patients starting antiretroviral therapy with CD4 cell counts of at least ...
- Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
Ann Intern Med
Jun 29, 2000
... < 0.001) and increase in CD4 lymphocyte count (P = 0.006 ...
- CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor C
Dec 10, 1996
... primary HIV-1 and soluble CD4 interacts specifically with CCR-5 ... . A gp120 fragment retaining the CD4-binding site and overlapping epitopes ... . Neutralizing antibodies directed against either CD4-induced or V3 epitopes on ... blocked the interaction of gp12O-CD4 complexes with CCR-5. These ...
- Identification of a major co-receptor for primary isolates of HIV-1.
Jul 25, 1996
... target cells requires cell-surface CD4 and additional host cell cofactors ...
- Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell res
Nov 16, 2001
... analysis of total HIV-specific CD4(+) and CD8(+) T-cell responses ... CD8(+) T cells. HIV-specific CD4(+) T-cell responses were present ... and total or Gag-specific CD4(+) T-cell response or between the frequency of HIV-specific CD4(+) and CD8(+) T cells. These ...
- A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients
Aug 04, 1998
... fructosamine levels, other metabolic parameters, CD4 lymphocyte counts, and HIV RNA ...
- Human chemokines: an update.
Annu Rev Immunol
Jul 29, 1997
... chemokine receptors which, together with CD4, were recognized as the binding ...
- Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.
Annu Rev Immunol
Aug 31, 1999
In addition to CD4, the human immunodeficiency virus (HIV) ... individual viral variants for different CD4+ target cells and the membrane ...
- Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
Nov 30, 1999
... found to replicate predominantly in CD4(+) T cells at the portal ...
- HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic:
Sep 21, 1999
... determine the HIV RNA and CD4 cell response to both initial ... MEASURES: Plasma HIV RNA and CD4 cell count response at week ... across most HIV RNA and CD4 cell strata, with significant increases ... explained by their suboptimal use. CD4 T cell counts remain above ...
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled
Jun 27, 1996
... transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to ... fusion and infection with normal CD4-positive human target cells. Fusin ...
- The dynamics of CD4+ T-cell depletion in HIV disease.
Apr 19, 2001
... size and composition of the CD4+ T-cell population is regulated ... homeostasis is often disturbed and CD4+ T cells are instead depleted ... from accelerated destruction of mature CD4+ T cells - sources of T ...
- CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
Dec 10, 1996
... -syncytium-inducing (NSI) phenotype with CD4+ T-cells. The primary binding ... CD4+ T cells or CCR-5-positive CD4- cells. We conclude that CD4 ... , including the V3 loop and CD4-induced epitopes, inhibited the interaction ... CCR-5, without affecting gp120-CD4 binding. Interference with HIV-1 ...
- Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and
Aug 25, 1998
... on reconstitution of antigen-specific CD4+ lymphocyte responses to important pathogens ... possible to quantitate antigen-specific CD4+ lymphocyte responses by flow cytometry ... HAART demonstrated strong CMV-specific CD4+ lymphocyte responses. These data indicate ...
- CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
Jan 02, 1997
... to function in association with CD4 to permit HIV-1 entry ... which these molecules serve as CD4-associated cofactors is unclear. In ... by the finding that (1) CD4-independent infection by these viruses ... expression renders human and nonhuman CD4-negative cell lines sensitive to ...
- Changes in thymic function with age and during the treatment of HIV infection.
Jan 19, 1999
... to reconstitute T cells expressing CD4 cell-surface antigens that are ... in their number of naive CD4-positive T cells. These cells ...
- HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-ce
May 28, 1997
... . Following protease inhibitor therapy, naive CD4+ T cells increased only if ... of therapy. Disruptions of the CD4+ TCR repertoire were most prevalent in patients with the lowest CD4+ T-cell counts. Antiviral or ... in previously disrupted repertoires. Thus, CD4+ T-cell death mediated by ...
- Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active
Sep 25, 1998
... ) decreases viral load and increases CD4 T-cell counts in patients ... infection. Whether HAART can improve CD4 T-cell function, and the ... for 12 months. We measured CD4-cell proliferation in response to ... can induce sustained recovery of CD4 T-cell reactivity against opportunistic ...
- Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppr
Nov 04, 2004
... proliferation. In contrast to CD4(+)CD25(-) T cells, CD4(+)CD25(+) T cells ... protein. The proliferative capacity of CD4 T cells to tuberculin, cytomegalovirus ... significantly increased following depletion of CD4(+)CD25(+) T cells. Furthermore, addition ... of p24-specific CD4(+) T cells among the CD4(+)CD25(+) T-cell ...
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Aug 14, 1996
... . CCR5, when expressed along with CD4, the HIV-1 receptor, allowed ...
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
Jul 25, 1996
... and RANTES inhibit infection of CD4+ T cells by primary, non ... -mediated cell-cell membrane fusion. CD4+ T cells from some HIV ... receptor CC-CKR-5 in CD4+, non-permissive human and non ...
- Declining morbidity and mortality among patients with advanced human immunodeficiency viru
N Engl J Med
Mar 26, 1998
... whom had at least one CD4+ count below 100 cells per ...
- Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-in
Jul 01, 1999
... of the pool of resting CD4+ T cells containing replication-competent ... isolated from the peripheral blood CD4+ T cells in three patients ... that large numbers of resting CD4+ T cells were cultured. Lymph ... in the pool of resting CD4+ T cells that contain replication ...
- Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed ind
Sep 26, 1996
... -1 but remain uninfected. The CD4+ T-cells of two of ...
- Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therap
Dec 02, 1997
The hypothesis that quiescent CD4+ T lymphocytes carrying proviral DNA ... was routinely recovered from resting CD4+ T lymphocytes. The frequency of resting CD4+ T cells harboring latent HIV ... nonevolving latent virus in resting CD4+ T cells should be considered ...
- Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation
Feb 23, 1998
... of treatment. In contrast, significant CD4+ T-cell repertoire perturbations were ... pretreatment perturbations, normalization of the CD4+ repertoire was observed in eight ... . These results indicate that, besides CD4+ cell count rise, an efficient ... allow qualitative modifications of the CD4+ repertoire balance.
- Dimeric association and segmental variability in the structure of human CD4.
Jun 19, 1997
CD4 is a co-receptor in ... with the lymphocyte kinase Lck. CD4 also serves as the high ... (HIV). The extracellular portion of CD4 comprises four immunoglobulin-like domains ... -D4). This part of human CD4 (residues 1-369) has been ...
- Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimen
J Infect Dis
Apr 27, 2000
... (HIV) RNA levels and peripheral CD4+ T cell counts was examined ... copies RNA/mL) generally had CD4+ T cell counts that remained ... weeks of follow-up. The CD4+ T cell response was directly ... weeks after virologic failure, subsequent CD4+ T cell decline was slower ...
- Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag f
J Exp Med
Feb 28, 2006
... presentation. Here we characterize the CD4(+) T cell immune response to ... )-gamma- and interleukin 2-producing CD4(+) T cells are elicited, including ... is observed. After subcutaneous vaccination, CD4(+) and IFN-gamma-dependent protection ... an unusually strong and protective CD4(+) T cell response, will improve ...
- Early establishment of a pool of latently infected, resting CD4(+) T cells during primary
Proc Natl Acad Sci U S A
Aug 20, 1998
... presence of latently infected, resting CD4(+) T cells carrying replication-competent ... generation of latently infected, resting CD4(+) T cells carrying integrated HIV ... ) and the frequencies of resting CD4(+) T cells carrying either integrated ... pool of latently infected, resting CD4(+) T cells as long as ...
- Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isol
Apr 17, 1998
... made by transducing parental HeLa-CD4 cells with the retroviral vector ... low and high amounts of CD4 were infected with equal efficiencies ... suggest that the concentrations of CD4 and CCR5 required for efficient ... limiting amount. We conclude that CD4 and CCR5 directly or indirectly ...
- High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation.
Proc Natl Acad Sci U S A
Nov 21, 2001
... and experimental animals, virus-specific CD4(+) T cell function is believed ... virus replication although HIV-specific CD4(+) T cells capable of producing ... was controlled. Further, HIV-specific CD4(+) T cells of viremic patients ... diminished proliferation of virus-specific CD4(+) T cells. Suppression of proliferation ...
- CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-trop
Aug 01, 1996
... requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric ... receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent ...
- Novel role of human CD4 molecule identified in neurodegeneration.
Apr 29, 1998
The human CD4 molecule (hCD4) is expressed on ...
- Energetics of the HIV gp120-CD4 binding reaction.
Proc Natl Acad Sci U S A
Sep 05, 2000
... interaction between the cellular receptor CD4 and gp120, the external envelope ... , thermodynamics, and kinetics of the CD4-gp120 interaction. The binding thermodynamics ... the core of gp120 upon CD4 binding. CD spectral studies and ...
- Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.
Jan 07, 1991
... an N-terminal fragment of CD4 has been determined to 2 ...
- Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected mon
Apr 07, 2005
... chemotactic for freshly isolated human CD4+ T cells, and chemotaxis was ... antiretroviral therapy. Because CCR5 on CD4+ T cells is found predominantly ...
- Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients w
Dec 03, 2004
... plasma HIV-RNA levels and CD4 cell counts during syphilis infection ... = 0.52) after syphilis treatment. CD4 cell counts were lower during ... load and reductions in the CD4 cell count were most substantial ... and significant decreases in the CD4 cell count. The findings underscore ...
- Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometr
J Clin Invest
Apr 24, 1997
... functional characteristics of cytomegalovirus-specific CD4+ memory/effector T cells in ... phenotype. Significantly, overall cytomegalovirus-specific CD4+ effector frequencies were markedly higher ... -/IL-4- phenotype. In contrast, CD4+ effector frequencies for heterologous, nonubiquitous ...
- Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+
Apr 28, 1997
Activation of CD4(+) T lymphocytes from human immunodeficiency ...
- Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cel
Nov 22, 1996
... an association between the surface CD4-gp120 complex and a 45 ... cells. However, infection of 3T3.CD4.401 cells with vaccinia-fusin ... in coprecipitation of fusin and CD4.401 molecules from their membranes ... association between fusin and the CD4-gp120 complex on cell membranes ...
- Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and
Proc Natl Acad Sci U S A
Jun 10, 1999
... , and a threshold number of CD4 and chemokine receptor molecules is ... to determine the number of CD4, CCR5, and CXCR4 antibody-binding ... -true memory cells compared with CD4+/CD45RO+/CD62L+ cells. Fresh PBDC ... looking at the modulation of CD4 or chemokine receptor expression by ...
- T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock.
Apr 02, 2001
... by a gradual loss of CD4+ T cells and progressive immune ...
- Virologic and immunologic consequences of discontinuing combination antiretroviral-drug th
N Engl J Med
Feb 08, 2001
... therapy. Plasma HIV RNA levels, CD4 cell counts, and drug susceptibility ... a median decrease in the CD4 cell count of 128 cells ... RNA levels and decreases in CD4 cell counts. Viral replicative capacity ... evaluated. Plasma HIV RNA levels, CD4 cell counts, and drug susceptibility ...
- Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects red
J Clin Invest
Jun 07, 1999
... and tips the balance toward CD4(+) cell repopulation. In this report ... that initial increases in blood CD4(+) cell counts on HAART are ...
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.
Jul 18, 2011
... clones of potent broadly neutralizing CD4-binding site antibodies that mimic binding to CD4. Despite extensive hypermutation, the new ...
- T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells.
Jan 21, 1994
The CD4 molecule is essential for binding ... this protease. Coexpression of human CD4 and CD26 in murine NIH ...
- Characterization of CD4(+) CTLs ex vivo.
May 22, 2002
... existence and relevance of cytotoxic CD4(+) T cells have been the ... show that a population of CD4(+) perforin(+) T cells is present ... . In comparison with more classical CD4(+) T cells, this subset displays ... include Ag experienced CD4(+) T cells. The existence of CD4(+) cytotoxic T ...
- Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cel
Apr 29, 2005
... lamina propria memory CD4+ T cells; that is, CD4-expressing T cells ... peak numbers of infected memory CD4+ T cells. Surprisingly, most of ... activation and thereby providing activated CD4+ T-cell targets to sustain ... apoptotic pathway in lamina propria CD4+ T cells, resulting in their ...
- Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue.
Nov 29, 2010
The mechanism by which CD4 T혻cells are depleted in혻 ... cultures of human tonsil tissue, CD4 T혻cells undergo a pronounced ... steps of reverse transcription prevent CD4 T혻cell death while inhibition ... by the majority of resting CD4 tonsil T혻cells leads to ...
- Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120.
Dec 07, 2009
... gp120 that binds to the CD4 receptor is vulnerable to antibodies ... structures for two poorly neutralizing, CD4-binding site (CD4BS) antibodies, F105 ... gp120 similar to those of CD4 and a rare, broadly neutralizing ...
- Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal target
Apr 27, 1999
... the cell surface expression of CD4 through a two-step process ... connects the cytoplasmic tail of CD4 with adaptor protein complexes (AP), thereby inducing the formation of CD4-specific clathrin-coated pits that ... receptor. Second, Nef targets internalized CD4 molecules for degradation. Here we ...
- Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-in
Oct 12, 1999
... virus entry by sequentially binding CD4 and chemokine receptors on the ... -1 isolates require interaction with CD4 to allow gp120 to bind ... isolate, ADA, to replicate in CD4-negative canine cells expressing human ... directly, without prior interaction with CD4. Thus, a major function of ...
- A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding
Apr 25, 1990
... chimpanzee or macaque CD4. We find that the CD4 sequences regulating cell ... ; in the simplest exchange, chimpanzee CD4 bearing human residue 87 supports syncytium formation, while human CD4 bearing chimpanzee residue 87 does ... of human cells expressing chimpanzee CD4 is insensitive to lysosomotropic agents ...
- HIV-1 RNA, CD4 T-lymphocytes, and clinical response to highly active antiretroviral therap
Nov 07, 2001
... if HIV-1 RNA and CD4 lymphocyte thresholds for the initiation ... with HIV disease progression within CD4 T-lymphoctye count strata. In ... , race, prior opportunistic infection, and CD4 T lymphocytes, < or = 200 x ... should place greater emphasis on CD4 lymphocyte than HIV-1 RNA ...
- The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Mar 21, 1997
... -tropic HIV-1 of HeLa-CD4 cells, CXCR-4 transfectants, and ...
- CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors
Mar 28, 1997
... -1) strain IIIB is a CD4-independent, dose-dependent inhibitor of ... as coreceptors in combination with CD4 for HIV-1 invasion. This ... , our studies provide for direct CD4-independent association of the viral ...
- Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptor
Apr 22, 2002
... type 1 (HIV-1) into CD4(+) T cells. We show that ... in live cells demonstrated that CD4, CCR5, and CXCR4 colocalized with ... showed that, in contrast to CD4 and CCR5, CXCR4 was associated ... and gp120 upon engagement of CD4 and CXCR4 by HIV-1 ...
- Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells f
Jan 04, 2001
... chronically HIV-infected patients with CD4 counts above 400/mm(3 ... /ml within 3 weeks. Significant CD4 T-cell proliferation and IFN ... rebounds in all patients. These CD4 responses lasted for less than ... only transiently mobilized HIV-specific CD4 T1-helper cells, which might ...
- Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in
Annu Rev Immunol
Aug 31, 1999
... depletes the immune system of CD4+ T cells, setting the stage ... recent evidence that productively infected CD4+ T cells play an important ... of stored virus, and restoring CD4+ T cell populations. I discuss ... trafficking to these changes in CD4+ T cell populations in LT ...
- Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-pr
Apr 12, 1994
... Nef causes a loss of CD4 from cell surfaces through a ... that Nef acts by inducing CD4 endocytosis, resulting in its degradation in lysosomes. CD4 down-regulation is strongly enhanced ... membrane-proximal residues of the CD4 cytoplasmic domain are sufficient to ...
- Quantifying residual HIV-1 replication in patients receiving combination antiretroviral th
N Engl J Med
May 27, 1999
... from latently infected resting memory CD4 lymphocytes; this finding raises serious ... -competent HIV-1 in resting CD4 lymphocytes on the basis of ... , replication-competent virus in resting CD4 lymphocytes was approximately six months ... half-life of latently infected CD4 lymphocytes of about six months ...
- Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5
Sep 23, 1996
... co-receptors, in addition to CD4, to infect target cells. The ...
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained
Oct 30, 2002
... cell response to HIV-infected CD4+ T cells in rare patients ...
- Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybr
Oct 17, 1988
... -binding portion of the human CD4 molecule linked to active regions ...
- Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reti
Jul 12, 1990
... the virus to the cellular CD4 receptor and mediates virus entry ... fusion of cells carrying the CD4 antigen. The expression of gp120 ... the HIV glycoprotein, this retained CD4 molecule prevents the fusion of ... glycoprotein. Expression of the retained CD4 molecule in human T cells ...
- Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfect
Apr 22, 1996
... studies indicated that their purified CD4+ lymphocytes were less susceptible to ... of HIV-1 than were CD4+ lymphocytes from the nonexposed controls ... the cell surface density of CD4 molecules, but was associated with ... -1beta. This relative resistance of CD4+ lymphocytes may contribute to protection ...
- Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in
Aug 20, 1999
... expression of its cellular receptor, CD4, through the combined actions of ... functional convergence strongly suggests that CD4 downregulation is critical for optimal ... of the viral envelope by CD4. CD4 is able to accumulate in ... ability to downregulate CD4, counteract this effect. CONCLUSIONS: The CD4-mediated 'envelope ...
- A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation an
Jan 28, 1999
... ) Nef downregulates surface expression of CD4, an integral component of the ... receptors and diminished transport of CD4 from the Golgi network to ... appears to be required for CD4 downregulation. As these tyrosine motifs ... is required for downregulation of CD4. This motif acts as an ...
- Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants o
Jan 25, 2002
... levels of P-glycoprotein expression, CD4-cell count, and HIV-1 ... had a greater rise in CD4-cell count (257 cells/microL ... best recovery of na챦ve CD4-cells. INTERPRETATION:The polymorphism MDR1 ...
- Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
Dec 02, 1997
... normal donors, activation of patient CD4 lymphocytes with immobilized antibodies to ...
- CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1
Sep 09, 2002
... with a comparable degree of CD4 depletion the imbalance in the ... with a similar degree of CD4 depletion despite large differences in ... relationship between immune activation and CD4 cell depletion in HIV disease ... strongly elevated immune activation induces CD4 cell depletion and not vice ...
- Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+
Proc Natl Acad Sci U S A
Dec 18, 2000
... number and fraction of dividing CD4(+) and CD8(+) T cells. Higher percentages of dividing CD4(+) and CD8(+) T cells were ... cell counts. Marked reductions in CD4(+) and CD8(+) T cell proliferation ... rearrangement excision circles. Division of CD4(+) and CD8(+) T cells increased ...
- Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monoc
Feb 21, 1989
... recombinant, soluble forms of the CD4 molecule (sCD4) block the infection ... lymphocytes by HIV-1, as CD4 binds the HIV envelope glycoprotein ... adsorption of virions to CD4 cells. Soluble CD4 prevents HIV infection of ... , but neither sCD4 nor anti-CD4 antibodies inhibit infection of glioma ...
- CD4+ count-guided interruption of antiretroviral treatment.
N Engl J Med
Nov 30, 2006
... deferral of therapy until the CD4+ count decreased to less than ... ), respectively. Adjustment for the latest CD4+ count and HIV RNA level ... antiretroviral therapy guided by the CD4+ count, as used in our ... a consequence of lowering the CD4+ cell count and increasing the ...
- Prognosis in HIV-1 infection predicted by the quantity of virus in plasma.
Jul 05, 1996
... those with normal numbers of CD4+ T cells, was directly related ... than was the number of CD4+ T cells.
- Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
Dec 15, 1986
... of the 58-kilodalton T4 (CD4) antigen on their surface. In ...
- Increasing mortality due to end-stage liver disease in patients with human immunodeficienc
Clin Infect Dis
Feb 22, 2001
... HIV RNA levels and/or CD4 cell counts of >200 cells ...
- Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type
Mar 12, 2001
... isolate, ADA, to replicate in CD4-negative canine cells expressing human ... . The gp120 changes responsible for CD4-independent replication were limited to ... of the temperature increased the CD4-independent phenotypes. A CCR5-binding conformation of gp120, achieved by CD4 interaction or by modification of ...
- HIV infection does not require endocytosis of its receptor, CD4.
Oct 11, 1988
... ). Internalization of CD4 molecules is observed after exposure of CD4+ T cells ... severely impair the ability of CD4 molecules to undergo endocytosis. Quantitative ... expressing wild-type or mutant CD4 molecules are equally susceptible to ... studies indicate that although the CD4 molecule can be internalized, HIV ...
- Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses i
J Infect Dis
Nov 03, 2000
... and no significant decrease in CD4 T cell percentage from baseline ...
- CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role
Proc Natl Acad Sci U S A
Oct 22, 1998
... cell (T)-tropic strains in CD4(+) T cells. Enhancement of T ... increased cell surface colocalization of CD4 and the T-tropic HIV ...
- Identification of the residues in human CD4 critical for the binding of HIV.
Jun 26, 1989
The CD4 molecule is a T cell ... . To define the sites on CD4 essential for binding to gp120 ... several truncated, soluble derivatives of CD4 and a series of 26 ... first 106 amino acids of CD4 (the V1 domain), a region ... -mediated cell fusion by soluble CD4 proteins depends on their association ...
- Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells:
Jun 16, 1988
... envelope glycoprotein in a human CD4+ cell line. Envelope expression is ... in the level of surface CD4 receptor molecules and correlates with the presence of intracellular envelope-CD4 receptor complexes. Cells expressing the ... , due to the absence of CD4 in the cell population, are ...
- A CXCR4/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-express
Oct 16, 1997
... rabies virus (RV) pseudotyped with CD4- and CXCR4-derived proteins selectively ... envelope protein. Envelope protein or CD4 antibodies blocked virus entry. Pseudotype ... spike protein (CXCR4-RV and CD4-RV). While CXCR4-RV was incorporated when expressed alone, CD4-RV incorporation required CXCR4-RV ...
- Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency
N Engl J Med
Sep 11, 1997
... and had 50 to 400 CD4 cells per cubic millimeter and ... changes in viral load and CD4 cell counts. RESULTS: The decrease ... -lamivudine group. The increase in CD4 cell counts over the first ... the viral load and the CD4 cell count persisted for up ...
- Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial.
Aug 03, 1999
... factors, age, sex, previous treatment, CD4-cell count (214/microL [SD14 ...
- Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells: a
Apr 19, 2004
... active antiretroviral therapy with a CD4 cell count-driven structured treatment ... the proportion of subjects maintaining CD4 cell count > 400 x 10 ... dynamic and predictive variables of CD4 cell loss. METHODS: The BASTA ... , controlled, prospective trial. Patients with CD4 cell counts > 800 x 10 ...
- Targeting of HIV- and SIV-infected cells by CD4-chemokine receptor pseudotypes.
Dec 16, 1997
Retroviral vectors containing CD4 and an appropriate chemokine receptor ... simian immunodeficiency virus (SIV). These CD4-chemokine receptor pseudotypes were able ... viral envelope glycoprotein for its CD4-chemokine receptor complex. This approach ...
- Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene.
Mar 12, 1987
... -cell interactions. Monoclonal antibodies against CD4 have been shown to block ... transmembrane signal transduction. The human CD4 glycoprotein has also been shown ... cDNA clones encoding the murine CD4 (L3T4) glycoprotein. Comparison of the mouse and human CD4 sequences reveals striking evolutionary conservation ...
- Biological properties of a CD4 immunoadhesin.
May 21, 1990
... virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120 ... -blocking properties of recombinant soluble CD4, and certain properties of IgG ... not allow ADCC towards uninfected CD4-expressing cells that have bound ... for the therapeutic application of CD4 immunoadhesins, particularly in the area ...
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5
Aug 14, 1996
... . Expression of CKR-5 with CD4 enables nonpermissive cells to form ... . Expression of CKR-5 and CD4 enables entry of a M ... syncytia with QT6 cells expressing CD4 and either Fusin or CKR ...